Manuscripts

Broglio F, E Arvat, A Benso et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 86: 5083-5086, 2001

Broglio F, C Gottero, F Prodam et al. Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab. 89(6):3062-5, 2004.

Gauna C, M Meyler, J Janssen et al. Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity. J Clin Endocrinol Metab 89:5035-5042, 2004.

Gauna C, P Delhanty, L Hofland et al. Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. J Clin Endocrinol Metab 90: 1055-1060, 2005.

Gauna C, P Delhanty, MO Van Aken et al. Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor. Mol Cell Endocrinol. 7;251:103-11, 2006.

Gauna C, Kiewiet RM, Janssen JA et al. Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions. Am J Physiol Endocrinol Metab 293(3):E697-704, 2007

Granata R, F Settani, F Catapano et al. Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling. Endocrinology  148(2):512-29, 2007

Gauna C, Uitterlinden P, Kramer P et al. Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats. Endocrinology 148(11):5278-87, 2007

Broglio F, Prodam F, Riganti F et al. The continuous infusion of acylated ghrelin enhances growth hormone secretion and worsens glucose metabolism in humans. J Endocrinol Invest 31(9):788-94, 2008

Togliatto G, Trombetta A, Dentelli P et al. Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes. Diabetes 59(4):1016-25, 2010

Granata R, Volante M, Settanni F et al. Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats. J Mol Endocrinol 45(1):9-17, 2010

Delhanty PJ, Sun Y, Visser JA et al. Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice. PLoS One 26;5(7):e11749, 2010

Granata R, Baragli A, Settanni F et al. Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol 45(3):107-18, 2010

Posters

Broglio F, F Prodam, F Riganti et al. Unacylated ghrelin enhances the early insulin response to meal, improves glucose metabolism and decreases free fatty acids levels. Endo2007, Toronto, June 2007.